Longevity for Us...

5fish

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New Breakthrough Paves the Way for Extending Human Lifespan – Scientists Successfully Transfer Longevity Gene. Researchers successfully transferred a longevity gene from naked mole rats to mice, leading to enhanced health and increased lifespan.
 

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Human longevity gene(s)...

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The study of longevity genes is a developing science. It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood. A few of the common variations (called polymorphisms) associated with long life spans are found in the APOE, FOXO3, and CETP genes, but they are not found in all individuals with exceptional longevity. It is likely that variants in multiple genes, some of which are unidentified, act together to contribute to a long life.
 

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Using gene knockouts — a research method that allows scientists to inactivate specific genes — a group of researchers genetically engineered mice to be deficient in CISD2. Previous research has already shown that the CISD2 gene exists on a region of the human chromosome that correlates to genetic differences in lifespan. Scientists speculate that CISD2 plays a role in keeping mitochondria working properly, which is important for maintaining cell growth and division.

Though the expression of CISD2 decreases on its own as mice age, researchers in this study discovered that both male and female mice without CISD2 all showed signs of premature aging, such as cell death and neuron and muscle cell degeneration. More recent research confirms that mice without the CISD2 gene have shorter lifespans, and suggests that CISD2 may affect genetic pathways linked to lifespan and other physiological signs of aging. Maintaining CISD2 expression could possibly lengthen the human lifespan or slow signs of aging.
 

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A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators.

Studies of humans who live longer than 100 years have shown that many share an unusual version of a gene called Forkhead box protein O3 (FOXO3). That discovery led Dr. Jihye Paik, associate professor of pathology and laboratory medicine at Weill Cornell Medicine, and her colleagues to investigate how this gene contributes to brain health during aging.
 

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About one in every 5,000 people in the United States is a centenarian—someone who’s 100 or more years old—and about 85 percent of them are women. As the New England Centenarian Study has shown, centenarians age slowly, delaying age-related diseases to much later in life.

Thomas Perls says we can do four things to increase our chances of living longer:

1. Manage stress
2. Eat right—and keep meat consumption to a minimum
3. Don’t smoke!
4. Exercise regularly

Genetics plays a huge role in our longevity. While getting to age 90 is roughly 30 percent genetics and 70 percent health behaviors, Perls says by age 110 it’s likely the opposite, or 70 percent genetic.
 

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sustainability?
Remember this thread...

 

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Here is a short video on odd demographics around the world... Ukraine demographic Prymid is spells trouble no youth...

 
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