Though I have a lot of relations I find more interesting since they have more recent and personal stories, the most notable probably are two Presidents I relate to.
The most notable would be President Thomas Jefferson.
My direct ancestor was his aunt, Judith Jefferson who was married to a George Farrar and resided in the same area of Virginia (the Farrars were a wealthy land owning family in the early days of Virginia), making Thomas Jefferson my 1st cousin 8 times removed. Our shared ancestor is Thomas Jefferson's grandparents, another Thomas Jefferson and a Mary Field.
My connection leads through a daughter of Judith, Mary Farrar, who married a sizable land owner Thomas Moore. He didn't serve in the Revolution, he was 60-ish years old during this, though is recognized as having contributed supplies to the cause. My ancestor was their daughter Elizabeth Moore who married a John Daws in Mecklenburg Co., Virginia. John Daws served first as a Corporal in a Virginia regiment. Then was recruited and served in Washington's Life Guard. Was serving in the Life Guard during the winter at Valley Forge.
My ancestor was their son Isaac H Daws who married a Susan C Roberts in Virginia then they travelled through Tennessee -> Alabama -> and finally resting in Dallas Co., Arkansas around 1860, eventually leading to Texas and to my mother, who was born in Texas.
I am also related to President Richard Nixon. He was a 7th cousin, 2 times removed. We relate through shared Quaker ancestry (where ironically we are both cousins to James Dean via the same ancestry).